Abstract
Feeding of cinnamic acid-[COOH- 14C] and mevalonic acid-[4- 14C] to roots of Pimpinella magna and degradation of the labelled furocoumarins show that the coumarin part of the furocoumarin skeleton is formed from cinnamic acid, whereas the two extra-carbons of the furan ring originate from C-4 and C-5 of mevalonic acid. The furan ring thus is likely to be formed by isoprenylation of a coumarin precursor followed by cyclization and loss of a 3-carbon unit. Comparison of the specific activities of the furocoumarins isolated from the two experiments indicates that the hydroxylation pattern is established before isoprenylation occurs. A tentative scheme for furocoumarin formation is discussed. Some evidence is presented that furocoumarins in Pimpinella magna are excretion products which are accumulated extracellulariy.
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