Abstract
Binding of gallium to transferrin has been studied with purified transferrin and with plasma. Binding affinity of transferrin for gallium is lower than those for indium, iron and scandium. Gallium in plasma behaves mostly as a free form and is partially associated with transferrin. In vivo localization of 67Ga in bones in influenced by the addition of carrier gallium. When 67Ga is injected in a carrier-free form, it is distributed both in the hematopoietic (marrow) and osteoplastic (metaphysis) tissues. With injection of carrier-added 67Ga it localizes markedly in the metaphysis. This observation suggests an iron-mimicking (hematopoietic) as well as bone-matrix-seeking character of gallium, probably originating from the dual biological behavior of gallium in plasma.
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