On the assignment of the absolute configuration at the isolated methyl branch in miyakosyne A, cytotoxic linear acetylene, from the deep-sea marine sponge Petrosia sp.

Abstract

Absolute configuration of miyakosyne A at its isolated branched methyl stereogenic center has been studied by chemical degradation in combination with esterification with the Ohrui's acid. Comparison of the 1H NMR data of the relevant diesters for the degradation product and the synthetic standards indicated the 14R-configuration.