On the assessment of the compliance factor in effectiveness evaluation of medication in patients with occlusive atherosclerosis

Abstract

Background: Non-observance by the patients of recommendations of the prescribed therapy is an important problem. Approximately the same amount of patients who take the prescribed medicines on a regular basis do not achieve the targeted levels of indices of blood lipids.Objective: The assessment of the compliance factor in effectiveness evaluation of medication in patients with occlusive atherosclerosis of internal carotid artery (ICA).Materials and methods: The research included 98 patients with occlusive atherosclerosis (ICA) and high risk according to the SCORE scale. All the patients were randomized into 2 groups: the first - 40 patients, 2-nd - 58 patients taking atorvastatin not on a regular basis or in a less dose. The observation period was 12 months. They assessed the level of cholesterol of low-density lipoprotein (CLDL) at the beginning and the end of the research.Results: In the 1st group they found out the significant decrease of CLDL in comparison with original data among men and women (р < 0,001). The targeted level of CLDL was achieved in 50% of patients. In the 2nd group of the patients, they pointed out a significant decrease of CLDL in comparison with the original data. Among the men the decrease of the level of CLDLappeared to be not significant. The targeted level of CLDL was achieved in 16% of patients (78% - women)Conclusion: 40% of the patients take recommended statin therapy on a regular basis during a year. Only 50% of dyslipidemia compliant patients achieved the targeted level of CLDL. Background: Non-observance by the patients of recommendations of the prescribed therapy is an important problem. Approximately the same amount of patients who take the prescribed medicines on a regular basis do not achieve the targeted levels of indices of blood lipids. Objective: The assessment of the compliance factor in effectiveness evaluation of medication in patients with occlusive atherosclerosis of internal carotid artery (ICA). Materials and methods: The research included 98 patients with occlusive atherosclerosis (ICA) and high risk according to the SCORE scale. All the patients were randomized into 2 groups: the first - 40 patients, 2-nd - 58 patients taking atorvastatin not on a regular basis or in a less dose. The observation period was 12 months. They assessed the level of cholesterol of low-density lipoprotein (CLDL) at the beginning and the end of the research. Results: In the 1st group they found out the significant decrease of CLDL in comparison with original data among men and women (р < 0,001). The targeted level of CLDL was achieved in 50% of patients. In the 2nd group of the patients, they pointed out a significant decrease of CLDL in comparison with the original data. Among the men the decrease of the level of CLDLappeared to be not significant. The targeted level of CLDL was achieved in 16% of patients (78% - women) Conclusion: 40% of the patients take recommended statin therapy on a regular basis during a year. Only 50% of dyslipidemia compliant patients achieved the targeted level of CLDL.