Abstract
We consider the situation wherein an individual is continuously exposed to an environmental agent and wherein the time interval is divided into k subintervals. Applying Moolgavkar and Venzon's (1979) two-stage model, we derive the probability distribution for the number of tumors and the incidence rates at the end of experiments. Within the context of the initiation and promotion phenomena, some data were generated by computer for analyzing the consequences of the model. The numerical results indicate that all the experimental findings are well interpreted by Moolgavkar's (1983) theory that initiation affects only the mutation rate of the normal cells while promotion affects only the birth rate of intermediate cells. Also, all known results from initiation and promotion experiments can be explained by the theory developed in this paper assuming the two-stage model of Moolgavkar and Venzon.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
