Abstract
Several valuable biologically active molecules can be obtained through C–H activation processes. However, the use of expensive and not readily accessible catalysts complicates the process of pharmacological application of these compounds. A plausible way to overcome this issue is developing and using cheaper, more accessible, and equally effective catalysts. First-row transition (3d) metals have shown to be important catalysts in this matter. This review summarizes the use of 3d metal catalysts in C–H activation processes to obtain potentially (or proved) biologically active compounds.
Highlights
The discovery of new biologically active substances represents an advance in the chemistry field and offers innovative chances for pharmacological and biomedical sciences
Titanium is another well-known and considerably cheap 3d metal which is underexplored in the C–H activation field [60], Scheme 4: (A) Known biological activities related to sulfur-containing compounds; (B and C) an example of a scandium-catalyzed C(sp3)–H alkylation of methyl thioether derivatives
Similar to the oxidation of alkanes to give alcohols and carbonyl compounds, vanadium complexes have been reported to mediate the hydroxylation of arenes, including the obtaining of Vanadium-based catalysts have been employed in carbon–carbon bond formation reactions, such as arene couplings, thereby proving especially useful in the synthesis of bioactive compounds, including natural compounds and biaryl chiral auxiliaries
Summary
The discovery of new biologically active substances represents an advance in the chemistry field and offers innovative chances for pharmacological and biomedical sciences. Catalysts based on these metals, are known to be efficient in C–H bond activation reactions affording the products in good yields and mild conditions, they are known to be usually expensive. Scandium-based catalysts have not been directly applied to the synthesis of known biologically active compounds via C–H activation reactions.
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