Abstract
Choline displaced [ 3H]QNB binding from rat brain muscarinic receptors competitively, (K i = 460 μM) but it was only 1/1000th as potent as ACh. Deanol was an extremely weak displacer of [ 3H]QNB binding while hemicholinium-3 was 50 times more potent than choline. Although brain levels of choline are well below its K i value for muscarinic receptors, choline may directly interact with rat brain muscarinic receptors in some circumstances.
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