Abstract
Publisher Summary The linear, time invariant compartmental models are of primary interest in the pharmacokinetics. The goal of the compartmental analysis is usually to find the simplest model that can fit the experimental data within the limits of measurement errors. This chapter describes the use of a new tool for tackling the a priori model selection and model simplification problems in compartmental analysis. This new tool is the concept of structural equivalence that is a generalization of the conventional concept of system equivalence and is closely related to the notion of structural identiflability. The results are based on the rigorous mathematical formulation. The chapter presents the mathematical results with two examples to show possible applications of the concept with respect to some practical problems of pharmacokinetics.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Mathematical and Computational Methods in Physiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
