Abstract
Acinar adenocarcinoma of varying degrees of differentiation is considered the most common histological form of prostate cancer. The major diagnostic criterion to be considered when choosing a method of treatment for prostate cancer is the morphological atypism of the glands, which is reflected in the Gleason grading scale, as well as the degree of expression of immunohistochemical markers, one of which is alpha-methylacyl-CoA racemase. However, the dependence of the expression of p504S on the degree of tumour grading by the Gleason grading system is not fully understood to date. The paper was aimed at establishing a relationship between the degree of differentiation of prostatic adenocarcinoma according to the Gleason grading scale and the degree of expression of the p504s IGC marker. Biopsy material obtained from 37 patients with prostate cancer was examined. According to the Gleason grading scale, the material was divided into three groups: 1-4 scores for the first group, 5-7 scores for the second group and 8-10 scores for the third group. IGC studies on determination of the p504s antigen expression were performed using monoclonal anti-AMACR/P504s. The analysis of the relationship between the degree of differentiation of the prostatic adenocarcinoma according to the Gleason scoring and the degree of expression of p504s IGC marker revealed a clear pattern and demonstrated a strong correlation (r=0,69) between these morphological characteristics of the tumour. The revealed pattern indicates the specificity of this marker in malignant tumour processes in the prostate gland, which is consistent with other studies, and enables to make more accurate differentiation of the tumour staging according to the Gleason grading scale. To a certain extent, this provides a basis for the selection of adequate methods of the treatment and for the improvement of prognostic criteria.
Highlights
Recent reports have stressed out a global increase in the identification of new pathogens, which are not characteristic for the human microbiota, as well as significant changes in the microbial composition of different biotopes of its body
The purpose of this study was to investigate the sensitivity of S. pluranimalium clinical isolate to antiseptics
The sensitivity of the studied S. pluranimalium isolate to antiseptics was determined by the method of double serial dilutions in liquid nutrient medium, in accordance with the Order No167 of the Ministry of Public Health of Ukraine on “On Approval of Training Guidance” Assessment of the sensitivity of microorganisms to antibiotics”
Summary
SENSITIVITY OF STREPTOCOCCUS PLURANIMALIUM CLINICAL ISOLATE TO ANTISEPTICS Faustova M.O. The purpose of this study was to investigate the sensitivity of S. pluranimalium clinical isolate to antiseptics. The sensitivity of the studied S. pluranimalium isolate to antiseptics was determined by the method of double serial dilutions in liquid nutrient medium, in accordance with the Order No167 of the Ministry of Public Health of Ukraine on “On Approval of Training Guidance” Assessment of the sensitivity of microorganisms to antibiotics”. The sensitivity of the clinical isolate under the study was determined to 0.05% for chlorhexidine, 0.05% for decasan, and 2.0% for chlorophyllipt extract. Among these antiseptics, the tested strain of streptococcus was the most sensitive to decasan, compared with chlorhexidine and natural extract of chlorophyllipt, the minimum inhibitory and minimum bactericidal concentrations of which exceeded these indicators of decasan.
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