On sleep slow oscillation- and theta- slowly alternating anodal transcranial direct current stimulation (tDCS) modulated learning and memory

Abstract

Event Abstract Back to Event On sleep slow oscillation- and theta- slowly alternating anodal transcranial direct current stimulation (tDCS) modulated learning and memory Lisa Marshall1* 1 University of Lübeck, Germany Slow-wave sleep facilitates the consolidation of declarative memories a process assumed to involve the redistribution of the memory representations from temporary hippocampal to neocortical long-term storage sites. The sleep slow oscillation (SO) (<1 Hz) originating from neocortical networks is presumed to orchestrates the brain electric activity involved in the dialogue between neocortex and hippocampus: The SOs not only temporally group cortical network activity into up- and down states but also, via efferent pathways, neuronal activity in other structures relevant to consolidation, i.e., in the thalamus, generating 10-15 Hz spindles, and in the hippocampus, generating sharp-wave ripples. The feedforward synchronizing effect of the SO enables memory-related inputs to be synchronously fed back from these (hippocampus, thalamus) and other structures to the neocortex. The co-occurrence in the neocortex of these feedback-inputs would be critical for the long-term storage of memories in neocortical networks. Indeed, induction of slow oscillations during NonREM sleep (but not during REM sleep or waking) by slowly alternating anodal transcranial direct current stimulation (so-tDCS) not only enhances and synchronizes spindle activity but also improves the consolidation of declarative memory. Completely opposite effects on EEG and memory performance are found for theta (~5Hz)-tDCS during NonREM sleep. Together, results reveal the strong functional relevance of the interaction between applied currents oscillating at a specific frequency and endogenous oscillatory brain electric activity, or brain state. Keywords: Brain activity, NonREM sleep Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Symposium: Oral Presentation Topic: Symposium 10: Entraining the brain? Effects of rhythmic brain stimulation protocols on oscillatory brain activity and behavior Citation: Marshall L (2011). On sleep slow oscillation- and theta- slowly alternating anodal transcranial direct current stimulation (tDCS) modulated learning and memory. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00528 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 09 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. Lisa Marshall, University of Lübeck, Lübeck, Germany, marshall@uni-luebeck.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lisa Marshall Google Lisa Marshall Google Scholar Lisa Marshall PubMed Lisa Marshall Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.