Abstract
On sialic acid transport and utilization by Vibrio cholerae
Highlights
The scavenging of host-derived sialic acid is important for a number of human pathogens during colonization of mammalian mucous membranes (Severi et al, 2007)
The authors were working on VC1929, a substrate-binding protein (SBP) from an uncharacterized tripartite ATP-independent periplasmic (TRAP) transporter comprising the VC1927-9 genes
Sharma et al (2011) present growth data for strain CD11, which contains a frameshift in VC1929, which shows that this strain is incapable of growth on sialic acid
Summary
The scavenging of host-derived sialic acid is important for a number of human pathogens during colonization of mammalian mucous membranes (Severi et al, 2007). We were surprised to read the recent publication by Sharma et al (2011) in this journal which claims that a different TRAP transporter is solely responsible for sialic acid transport in this important pathogen.
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