On pooling data summaries in the absence of interactions “response-by-study”

Abstract

The standard hypothesis testing procedure in meta-analysis (or multi-center clinical trials) in the absence of treatment-by-center interaction relies on approximating the null distribution of the standard test statistic by a standard normal distribution. For relatively small sample sizes, the standard procedure has been shown by various authors to have poor control of the type I error probability, leading to too many liberal decisions. In this article, two test procedures are proposed, which rely on thet—distribution as the reference distribution. A simulation study indicates that the proposed procedures attain significance levels closer to the nominal level compared with the standard procedure.