Abstract
We have developed an instrument for non-invasive optical imaging of the human brain that produces on-line images with a temporal resolution of 160 ms. The imaged quantities are the temporal changes in cerebral oxy-hemoglobin and deoxy-hemoglobin concentrations. We report real-time videos of the arterial pulsation and motor activation recorded on a 4 x 9 cm 2 area of the cerebral cortex in a healthy human subject. This approach to optical brain imaging is a powerful tool for the investigation of the spatial and temporal features of the optical signals collected on the brain.
Highlights
Near-infrared spectroscopy (NIRS) is an effective technique for the non-invasive monitoring of cerebral hemodynamics and oxygenation
We have developed an instrument for non-invasive optical imaging of the human brain that produces on-line images with a temporal resolution of 160 ms
We report real-time videos of the arterial pulsation and motor activation recorded on a 4 × 9 cm2 area of the cerebral cortex in a healthy human subject
Summary
Near-infrared spectroscopy (NIRS) is an effective technique for the non-invasive monitoring of cerebral hemodynamics and oxygenation. Reported acquisition times per image are 3-5 s [5,13], < 30 s [14], 2.5 min [15], several hours [16,17], 1-3 days [18], and not-quantified “slow data acquisition rate” [19], and “long measurement times” [20] While these acquisition times can be appropriate for structural imaging or for the monitoring of slow dynamic processes, it is desirable to exploit the capability of high temporal resolution afforded by optical methods in functional brain imaging. The first one is the mapping of the arterial pulsation at rest; the second and the third videos report the spatially-resolved hemodynamics observed on the primary motor cortex during contralateral hand tapping
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