Abstract
Background Aber Instruments first introduced the concept of using disposable live-biomass probes in 2009 [1]. The probe has been carefully designed to be welded into most single use bioreactors and is suitable for bags with agitators eg the Hyclone SUB and the Sartorius Stedim Biostat Cultibag STR, or those using the rocker type platform eg Sartorius Stedim Biostat Cultibag RM and GE Wave bioreactors . The disposable biomass probe has four electrodes with the same dimensions as the existing reusable production biomass probes with flush platinum electrodes that are used in cGMP manufacture worldwide. The electrode support material is HDPE that meets FDA and USP Class VI requirements and the probe can withstand gamma sterilisation and be stored for prolonged periods before use. The disposable probe is easily connected to a mini-lightweight Futura preamplifier so that the weight load or torque on the bag is minimal and the bulk of the electronics is then located well away from the bag. The disposable probe has already been welded into different bags including Sartorius Stedim Biotech CultiBag RM bioreactors.
Highlights
Aber Instruments first introduced the concept of using disposable live-biomass probes in 2009 [1]
The disposable probe has already been welded into different bags including Sartorius Stedim Biotech CultiBag RM bioreactors
In the very first tests with the disposable probe installed in a 5L Sartorius Stedim Biotech CultiBag RM filled with just media, the unfiltered capacitance and conductivity profiles were shown to become increasingly noisier as the speed of the rocking action was increased
Summary
Aber Instruments first introduced the concept of using disposable live-biomass probes in 2009 [1]. The probe has been carefully designed to be welded into most single use bioreactors and is suitable for bags with agitators eg the Hyclone SUB and the Sartorius Stedim Biostat Cultibag STR, or those using the rocker type platform eg Sartorius Stedim Biostat Cultibag RM and GE Wave bioreactors. The electrode support material is HDPE that meets FDA and USP Class VI requirements and the probe can withstand gamma sterilisation and be stored for prolonged periods before use. The disposable probe is connected to a mini-lightweight Futura preamplifier so that the weight load or torque on the bag is minimal and the bulk of the electronics is located well away from the bag. The disposable probe has already been welded into different bags including Sartorius Stedim Biotech CultiBag RM bioreactors
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