Abstract
On-line process control with a SAW (surface acoustic wave) sensor-based gas-sensor microsystem (SAGAS PC = surface acoustic wave based aroma and gas analyzing system) for industrial applications is presented. The monitoring of the gradient former of a preparative HPLC system is a useful tool for the on-line process control of pilot plant production. All applications deal with the detection and subsequent qualification as well as quantitation of volatile organic compounds (VOCs), for example, organic solvents or even water, by investigating their vapor with the SAGAS PC-system. To demonstrate the suitability of the system for the above-mentioned purpose different examples of typical binary solvent mixtures for normal phase (NP) HPLC have been chosen. The accuracy, precision, and robustness of the applied method are determined, and the results meet the specification requirements. Furthermore, on-line measurements in a pilot plant environment are presented.
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