On Line Colorimetric Determinations of Transvascular Fluid and Protein Transport in Isolated Lobes

Abstract

A commonly used method to estimate transvascular fluid exchange in organs is based on measurements of weight changes with time. Following changes in pulmonary capillary hydrostatic pressure (Pc), weight changes in characteristic fashion. A fast change in weight, assumed to represent vascular volume adaptations, is followed by slow exponential changes, which are thought to represent transvascular fluid exchange associated with the change in Pc. The analysis of the slow exponential weight change constitutes one of the most common approaches to determinations of vascular membrane and transvascular force readjustment in isolated lung preparations such as that depicted in Figure 1.