On elastin in aorta of SHRSP (2).

Abstract

As described above, the proportion of elastin in aorta was high in young rats and decreased with age. And its amino acid composition showed that the content of polar amino acids increased with age. Moreover, the SHRSP showed a high proportion of elastin and a high content of polar amino acids in amino acid compositions after 3 months old, as compared with the Wistar-Kyoto rats. These results indicate that the aging process in the aorta of SHRSP proceeds earlier than in the Wistar-Kyoto rats, but the effects of hypertension upon the arterial wall must be considered.On the other hand, for the SHRSP fed with white fish meal or casein diet, the proportion of elastin in aorta was higher than in the SHRSP fed with a stock chow diet. This became more remarkable with age. It should be expected that there is some relationship between these results and the inhibition of blood pressure elevation and the decrease in incidence of stroke in SHRSP fed with these experimental diets.