On-Demand Release of Drug from Magnetic Nanoparticle-Loaded Alginate Beads.

Dung The Nguyen,Van-Thao Ta,Duc-Minh Vu,Nguyet-Minh Nguyen,Minh-Duc Tran,Dang Quoc Thuyet

doi:10.1155/2021/5576283

Abstract

Targeted delivery and controlled release of drugs has been considered to be an important therapeutic approach since it could allow a better treatment efficiency and less side effects. In this research, magnetite Fe3O4 nanoparticles were successfully synthesized via the coprecipitation method and then loaded in alginate beads with berberine as a drug model for drug release application. Various factors such as pH values of the suspended environment and surface modifications of the drug carrier could be exploited to adjust the amount of drug release. More importantly, the amount of drug release could be effectively controlled by an on-off switching operation of a static magnetic field.

Highlights

Magnetic nanoparticles are of great interest because of their action-at-a-distance behavior with an applied magnetic field
Utilization of magnetic field for biomedical applications including contrast agent, hyperthermia, and drug delivery has been bursting since the last decade due to the development of concepts and tools derived from nanotechnology [1,2,3]
Instead of exploiting benefits of an alternative current field, we found that an on-demand drug release via the on-off operation of a static magnetic field could offer a mechanism to minimize drug release during delivery process and to maintain drug level at reasonable levels within the desired therapeutic range for a long time

Summary

Introduction

Magnetic nanoparticles are of great interest because of their action-at-a-distance behavior with an applied magnetic field. Important capabilities of magnetic nanoparticles are the external controllability of magnetic forces. Utilization of magnetic field for biomedical applications including contrast agent, hyperthermia, and drug delivery has been bursting since the last decade due to the development of concepts and tools derived from nanotechnology [1,2,3]. As a part of this, numerous research studies have been conducted with attempts to exploit significant advantages of delivery and controlled release of drug molecules, including the ability to target specific locations in the body and the reduction of the quantity of drug needed for better treatment efficiency with minimum severe side effects. It has been reported and reviewed that a magnetostatic field was able to accumulate magnetic nanoparticles at a targeted location even for a deep target, and drug molecules which attached onto the magnetic nanoparticles could be successfully delivered [7, 8]

Methods

Results

Conclusion