On Convergence for Piecewise Affine Models of Gene Regulatory Networks via a Lyapunov Approach

Abstract

In this paper, we analyse convergence and stability properties for piecewise affine models of gene regulatory networks, by means of piecewise quadratic Lyapunov functions. In the first part, we present the piecewise affine model of a gene regulatory network then, after proving a result on the existence of a minimal, attractive, and positively invariant box, we describe a linear matrix inequalitie framework to construct a Lyapunov function for the system. In the second part of the work, after a characterization of the system solutions when considering also isolated Zeno behavior of the trajectories, a monotonicity property of the so found Lyapunov function is formally proved, together with a result on the convergence of the trajectories, in the sense of measure. Finally, we present two examples, showing the applicability and utility of the main theoretical results previously explained.