Abstract
AbstractTwo efficient preparations of the title compound, one from common C19‐steroids, the other frm digitoxigenin, are described. The less active minor epimer (21S)‐methyldigitoxigenin was also obtained and characterized. The positive inotropic effects and margins of safety of the two C(21)‐epimers (tested as glucosides) are discussed in terms of the topological properties of the Digitalis receptors.
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