Abstract
BackgroundDiabetes has become one of the hot topics in life science researches. To support the analytical procedures, researchers and analysts expend a mass of labor cost to collect experimental data, which is also error-prone. To reduce the cost and to ensure the data quality, there is a growing trend of extracting clinical events in form of knowledge from electronic medical records (EMRs). To do so, we first need a high-coverage knowledge base (KB) of a specific disease to support the above extraction tasks called KB-based Extraction.MethodsWe propose an approach to build a diabetes-centric knowledge base (a.k.a. DKB) via mining the Web. In particular, we first extract knowledge from semi-structured contents of vertical portals, fuse individual knowledge from each site, and further map them to a unified KB. The target DKB is then extracted from the overall KB based on a distance-based Expectation-Maximization (EM) algorithm.ResultsDuring the experiments, we selected eight popular vertical portals in China as data sources to construct DKB. There are 7703 instances and 96,041 edges in the final diabetes KB covering diseases, symptoms, western medicines, traditional Chinese medicines, examinations, departments, and body structures. The accuracy of DKB is 95.91%. Besides the quality assessment of extracted knowledge from vertical portals, we also carried out detailed experiments for evaluating the knowledge fusion performance as well as the convergence of the distance-based EM algorithm with positive results.ConclusionsIn this paper, we introduced an approach to constructing DKB. A knowledge extraction and fusion pipeline was first used to extract semi-structured data from vertical portals and individual KBs were further fused into a unified knowledge base. After that, we develop a distance based Expectation Maximization algorithm to extract a subset from the overall knowledge base forming the target DKB. Experiments showed that the data in DKB are rich and of high-quality.
Highlights
Diabetes has become one of the hot topics in life science researches
To ensure the high-quality of the data in our built knowledge base (KB), we describe a detailed method for knowledge extraction from vertical portals
We develop a distance-based EM algorithm to extract a subset from the unified KB forming the target Diabetes-centric knowledge base (DKB)
Summary
Diabetes has become one of the hot topics in life science researches. To support the analytical procedures, researchers and analysts expend a mass of labor cost to collect experimental data, which is error-prone. To reduce the cost and to ensure the data quality, there is a growing trend of extracting clinical events in form of knowledge from electronic medical records (EMRs). About 92.3 million and 63 million people in China and India suffer from this metabolic disorder respectively. In this context, diabetes has become a hot topic in life science researches recently and there is a growing trend of using EMRs as a source of clinical information to support the analytical procedures. Suna et al [2] designed and constructed a diabetes knowledge graph from EMRs and proposed a deep
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