Abstract
In the autumn of 1862, feeling assured that, besides the known normal crystalloid compounds found in urine, this secretion contained colloid substances, I submitted samples of the healthy secretion, after concentration, first, to the process of dialysis, and then to the action of reagents, and finally succeeded in precipitating with alcohol a colloid substance exhibiting a faintly acid or neutral reaction, and containing a small proportion of ash. For a while my endeavours to obtain a definite compound from this amorphous mass were fruitless, until, on observing that basic acetate of lead produced a precipitate in its aqueous solution, I thought of examining this precipitate, and, by decomposing it with sulphuretted hydrogen, found it to consist of an organic acid combined with lead. This new acid is possessed of the properties of a colloid substance; it may be considered as having a definite combining proportion or equivalent weight, and is undoubtedly destined to become of great importance in physiological chemistry.
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