Abstract
Recent meta-analysis and some studies have shown that patients with type 2 diabetes mellitus have an increased risk of fractures despite their elevated bone mineral density, suggesting that diabetes mellitus is an underlying illness for "lifestyle-related disease associated osteoporosis". The fracture risk observed in these patients was higher than those expected by BMD, indicating that bone fragility in these patients may be caused by poor bone quality composed by structural and material properties such as excessive glycated bone collagen, low bone turnover, thinner cortical thickness, and increased cortical porosity. Prevention of fracture in these patients may be achieved by keeping good blood glucose levels treated with diabetic drugs that do not affect on bone metabolism.
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