OMNiMIPs: ONE MONOMER MOLECULARLY IMPRINTED POLYMERS

Abstract

Event Abstract Back to Event OMNiMIPs: ONE MONOMER MOLECULARLY IMPRINTED POLYMERS Md Ragib Hasan1, Arjun Pandey1 and David Spivak1* 1 Louisiana State University, United States There is a tremendous interest in the analytical applications of molecularly imprinted polymers (MIPs), which can serve as the molecular recognition element of sensors, immunoassays, and separation media. However, difficulties with formulation variables and the need for empirical optimization have inhibited the widespread use of MIPs by the general scientific community. While investigating new crosslinkers for molecular imprinting, we have recently discovered a much simpler approach to MIP formation which utilizes a single crosslinking monomer, NOBE, in addition to template, solvent and initiator. This new formulation eliminates variables such as choice of functional monomer (FM) and crosslinker (XL), the ratio of functional monomer/crosslinker (FM/XL), and the ratio of functional monomer/template which normally complicates MIP design. Thus we refer to this type of imprinted material as an OMNiMIP, which stands for One MoNomer Molecularly Imprinted Polymer. Herein we report that another crosslinking monomer, N-acetyl glycine (NAG) has shown improved enantioselectivity when used in conjunction with the functional monomer methacrylic acid. Initial studies on using NAG as an OMNiMIP have indicated that it might show improvement over NOBE under thermal polymerization conditions. The origins of the enhanced selectivity could arise from both molecular and macromolecular contributions. At the molecular level, selectivity of template binding may be enhanced by cooperative 1,3 interactions of the amide and carbonyl group of NAG, versus the more distant 1,5 interaction of NOBE. From a materials point of view, the shorter length of NAG may provide a better resolved binding site by wrapping more snugly around the template molecule. The synthesis of the NAG monomer and its performance for chiral selectivity will be presented. Keywords: Enanatioselectivity, N-acetyl glycine (NAG), N, O-Bismethacryloyl ethanolamine (NOBE), Molecular recognition element, molecularly imprinted polymer Conference: National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE) 45th Annual Conference , Orlando, Florida, United States, 17 Sep - 20 Sep, 2018. Presentation Type: Poster Presentation Topic: Organic Chemistry Citation: Hasan M, Pandey A and Spivak D (2019). OMNiMIPs: ONE MONOMER MOLECULARLY IMPRINTED POLYMERS. Front. Chem. Conference Abstract: National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE) 45th Annual Conference . doi: 10.3389/conf.fchem.2018.01.00043 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Oct 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. David Spivak, Louisiana State University, Baton Rouge, United States, dspivak@lsu.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Md Ragib Hasan Arjun Pandey David Spivak Google Md Ragib Hasan Arjun Pandey David Spivak Google Scholar Md Ragib Hasan Arjun Pandey David Spivak PubMed Md Ragib Hasan Arjun Pandey David Spivak Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.