Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease frequently characterized by mucosal eosinophilia likely influenced by elevated levels of type 2 cytokines, notably IL-13, and CCR3 ligands of the eotaxin family. Recent reports demonstrate proton pump inhibitor omeprazole has suppressive effects on eotaxin-3 responses to type 2 cytokines in esophageal squamous cells. We aimed to evaluate IL-13-mediated expression of eotaxin-3 by human bronchial epithelial cell line (BEAS-2B) and primary human sinonasal epithelial cells (SNEC) and the inhibitory effects of omeprazole on IL-13-induced eotaxin-3 responses in airway epithelial cells.
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