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Abstract
Aim: Adipose tissue is an endocrine organ synthesizes a number of biologically active compounds known as adipocytokines that regulate glucose and lipid homeostasis. Imbalance in adipokines production and secretion by specialized adipose tissue types can be linked to metabolic and cardiovascular diseases. Due to its anatomic and functional proximity to the myocardium epicardial fat activity can be most important in the development of coronary heart disease (CHD). Omentin-1 is an anti-inflammatory adipokine expressed in stromal vascular cells of the adipose tissue and suggested to play a role in obesity, diabetes and CHD progression. Our hypothesis was that Omentin 1 gene (ITLN1) expression variations in epicardial adipose tissue can be associated with obesity-related CHD.
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