Abstract
BackgroundOmentin is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of omentin with the number of metabolic risk factors.FindingThe study population comprised 201 Japanese men who underwent annual health checkups. Plasma omentin levels were determined by enzyme-linked immunosorbent assay. We divided the subjects into 4 groups according to omentin levels. A reduction of plasma omentin levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, dyslipidemia, high blood pressure and glucose intolerance.ConclusionsCirculating omentin levels negatively correlated with the multiplicity of metabolic risk factors, suggesting that omentin acts as a biomarker of metabolic disorders.
Highlights
Omentin is an adipocytokine that is abundantly expressed in visceral fat tissue
Accumulating evidence indicates that adipose tissue is an active endocrine organ that produces various bioactive substances, known as adipocytokines or adipokines [4,5]
Excess adipose mass observed in obese individuals is linked with increased production of many adipocytokines including tumor necrosis factor-α and interleukin-6, which potentially promotes metabolic dysfunction [5,6]
Summary
Omentin is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of omentin with the number of metabolic risk factors. Excess adipose mass observed in obese individuals is linked with increased production of many adipocytokines including tumor necrosis factor-α and interleukin-6, which potentially promotes metabolic dysfunction [5,6]. While omentin is highly expressed in human visceral fat tissue, circulating omentin levels are reduced in obese subjects [12].
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