Abstract

Omentin-1 is an adipokine which could have a protective role against the manifestation of atherosclerosis. Only limited data are available on omentin-1 serum values in patients with premature clinical manifestations of atherosclerosis. We tested omentin-1 in human serum by ELISA method in 61 individuals with a premature manifestation of coronary artery disease (CAD), 40 patients with metabolic syndrome and 40 healthy control subjects. Omentin-1 serum levels were significantly lower in patients with CAD (103.1±62.7 mg/L) compared to metabolic syndrome (668.2±339.6 mg/L) and healthy subjects (623.0±373.5 mg/L) (P < 0.01). In CAD patients, omentin-1 serum levels did not differ between patients sampled in the acute phase of myocardial infarction (n = 28; 110.3±82.4 mg/L) and in the chronic phase several months or years after myocardial infarction (n = 33; 97.0±39.3 mg/L) (P = 0.41). We found a weak positive correlation between omentin-1 and body mass index (r = 0.21, P = 0.014). No significant correlation was found between peak cardiac troponin T and omentin-1 (correlation coefficient r = 0.118, P = 0.406). Serum omentin-1 seems to be a useful biomarker of coronary artery disease across the whole age spectrum.

Highlights

  • IntroductionOmentin-1 (intelectin-1, intestinal lactoferin receptor, endothelial lectin HL-1, galactofuranose-binding lectin) is a newly identified secretory protein that is highly and selectively expressed in the visceral relative to the subcutaneous adipose tissue (adipokine)

  • Omentin-1 is a newly identified secretory protein that is highly and selectively expressed in the visceral relative to the subcutaneous adipose tissue

  • The study showed that patients with premature coronary artery disease (CAD) had significantly lower serum omentin-1 levels than patients with metabolic syndrome and healthy controls

Read more

Summary

Introduction

Omentin-1 (intelectin-1, intestinal lactoferin receptor, endothelial lectin HL-1, galactofuranose-binding lectin) is a newly identified secretory protein that is highly and selectively expressed in the visceral relative to the subcutaneous adipose tissue (adipokine). The mature omentin-1 is a secretory glycoprotein consisting of 295 aminoacids and 1-linked oligosacharides, and its basic structural unit is a 120-kDa homotrimer in which 40-kDa polypeptides are bridged by disulfide bonds. Omentin has been identified in other tissues at lower expression levels such as Paneth cells, endothelial cells, and visceral adipose stromal-vascular cells[1]. A homologue of omentin has been identified which shares 83% amino acid identity with omentin-1 and is referred to as omentin-2. Omentin 1 and omentin 2, are localized adjacent to each other in a chromosomal region which has been linked to type 2 diabetes in several populations[2]. Omentin-1 has been shown to be the major circulating isoform in human plasma

Objectives
Methods
Results
Conclusion

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.