Abstract
Omentin-1 is an adipokine which could have a protective role against the manifestation of atherosclerosis. Only limited data are available on omentin-1 serum values in patients with premature clinical manifestations of atherosclerosis. We tested omentin-1 in human serum by ELISA method in 61 individuals with a premature manifestation of coronary artery disease (CAD), 40 patients with metabolic syndrome and 40 healthy control subjects. Omentin-1 serum levels were significantly lower in patients with CAD (103.1±62.7 mg/L) compared to metabolic syndrome (668.2±339.6 mg/L) and healthy subjects (623.0±373.5 mg/L) (P < 0.01). In CAD patients, omentin-1 serum levels did not differ between patients sampled in the acute phase of myocardial infarction (n = 28; 110.3±82.4 mg/L) and in the chronic phase several months or years after myocardial infarction (n = 33; 97.0±39.3 mg/L) (P = 0.41). We found a weak positive correlation between omentin-1 and body mass index (r = 0.21, P = 0.014). No significant correlation was found between peak cardiac troponin T and omentin-1 (correlation coefficient r = 0.118, P = 0.406). Serum omentin-1 seems to be a useful biomarker of coronary artery disease across the whole age spectrum.
Highlights
IntroductionOmentin-1 (intelectin-1, intestinal lactoferin receptor, endothelial lectin HL-1, galactofuranose-binding lectin) is a newly identified secretory protein that is highly and selectively expressed in the visceral relative to the subcutaneous adipose tissue (adipokine)
Omentin-1 is a newly identified secretory protein that is highly and selectively expressed in the visceral relative to the subcutaneous adipose tissue
The study showed that patients with premature coronary artery disease (CAD) had significantly lower serum omentin-1 levels than patients with metabolic syndrome and healthy controls
Summary
Omentin-1 (intelectin-1, intestinal lactoferin receptor, endothelial lectin HL-1, galactofuranose-binding lectin) is a newly identified secretory protein that is highly and selectively expressed in the visceral relative to the subcutaneous adipose tissue (adipokine). The mature omentin-1 is a secretory glycoprotein consisting of 295 aminoacids and 1-linked oligosacharides, and its basic structural unit is a 120-kDa homotrimer in which 40-kDa polypeptides are bridged by disulfide bonds. Omentin has been identified in other tissues at lower expression levels such as Paneth cells, endothelial cells, and visceral adipose stromal-vascular cells[1]. A homologue of omentin has been identified which shares 83% amino acid identity with omentin-1 and is referred to as omentin-2. Omentin 1 and omentin 2, are localized adjacent to each other in a chromosomal region which has been linked to type 2 diabetes in several populations[2]. Omentin-1 has been shown to be the major circulating isoform in human plasma
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Schedule a callMore From: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
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