Abstract
ObjectivePrevious studies found inconsistent results on the relationship between diabetes mellitus and concentrations of omentin-1. This study performed a systematic review and meta-analysis to summarize previous findings on this relationship.MethodsStudies related to this outcome were obtained using a systematic search in the electronic databases of Cochrane Library, PubMed, Embase, SCOPUS, Google Scholar, gray literature and Web of Science in September 2019. The random effects model was used to measure the strength of the association between diabetes mellitus and concentrations of omentin-1, using standardized mean difference.ResultsForty-two eligible studies were included in the final meta-analysis. There was no significant difference in omentin-1 concentration between patients with type 1 diabetes mellitus and the controls. On the other hand, lower concentration levels of omentin-1 were observed in patients with gestational diabetes mellitus (standardized mean difference:-0.44, 95% confidence interval:-0.76; -0.12, p = 0.007), or type 2 diabetes mellitus (standardized mean difference: -1.74, 95% confidence interval: -2.31; -1.16, p< 0.001) than in the controls.ConclusionDecreased omentin-1 concentrations may be an important indicator for gestational diabetes mellitus and type 2 diabetes mellitus. More studies are needed to validate this hypothesis and evaluate the role of omentin-1 concentrations in type 1 diabetes mellitus.
Highlights
Diabetes mellitus (DM) is characterized by a set of metabolic disorders which are related to high blood sugar levels over a lengthy interval of time and may cause many complications [1]
Decreased omentin-1 concentrations may be an important indicator for gestational diabetes mellitus and type 2 diabetes mellitus
A total of 1,617 articles were identified from the six databases as follows: 196 from PubMed, 275 from Embase, 288 from Web of Science, 629 from Google Scholar, 32 from Cochrane Library and 197 from SCOPUS
Summary
Diabetes mellitus (DM) is characterized by a set of metabolic disorders which are related to high blood sugar levels over a lengthy interval of time and may cause many complications [1]. DM is classified into three types: gestational diabetes mellitus (GDM), type 1 diabetes mellitus (T1DM), and type 2 diabetes mellitus (T2DM) [2, 3]. The development of DM has been a prominent global public health issue [4]. Many adipocyte-secreted proteins as well as adipokines have been introduced as novel links to DM [6]. It is widely accepted that the adipokines participate in many metabolic processes, including energy expenditure, appetite control, insulin sensitivity, and regulation of adipogenesis [7, 8]
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