Abstract
BackgroundOmentin-1 is a novel adipocytokine that is related to atherosclerosis-based ischaemic cardiovascular disease and stroke. Previous studies have linked its lower levels with poor stroke outcomes. We aimed to assess the level of serum omentin-1 as a prognostic marker in patients with large artery ischaemic stroke.MethodsFifty ischaemic stroke patients suffering large artery ischaemic stroke and another 50 subjects without a prior history of strokes were recruited. All participants were subjected to neurological examinations, echocardiography and laboratory investigations including a lipid profile and HBA1c. Carotid intima-media thickness (IMT) was measured for all participants. Stroke patients were evaluated by the National Institute of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS). Infarction volume was measured by magnetic resonance image (MRI) and serum level of omentin-1 was gauged for all participants.ResultsCarotid IMT significantly increased in stroke patients compared to control subjects. While serum omentin-1 levels were higher in control non-diabetic subjects, they were lower in diabetic patients with ischaemic stroke. Serum omentin-1 levels were inversely correlated with NIHSS, carotid IMT, infarction volume and mRS scores in all stroke patients. Serum omentin-1 level less than 24.5 ng/ml showed 93.7%sensitivity and 44.4% specificity in prediction of poor stroke outcome while values less than 27.8 ng/ml in non-diabetic stroke patients had sensitivity and specificity with 87.5% and 55.6% respectively.ConclusionLower levels of serum omentin-1 are associated with increased ischaemic stroke severity and poor functional outcome.
Highlights
Omentin-1 is a novel adipocytokine that is related to atherosclerosis-based ischaemic cardiovascular disease and stroke
The current study aims to assess the level of serum omentin-1 as a prognostic biomarker in patients with large artery ischaemic stroke
The results of our study revealed that serum omentin-1 levels in ischaemic stroke patients were significantly inversely correlated with National Institute of Health Stroke Scale (NIHSS), carotid intima-media thickness (IMT), infarction volume and 3-month modified Rankin Scale (mRS) scores in diabetic and nondiabetic patients as illustrated in Figs. 1 and 2 respectively
Summary
Omentin-1 is a novel adipocytokine that is related to atherosclerosis-based ischaemic cardiovascular disease and stroke. Previous studies have linked its lower levels with poor stroke outcomes. We aimed to assess the level of serum omentin-1 as a prognostic marker in patients with large artery ischaemic stroke. The overall crude prevalence rate of stroke is 963/100,000 inhabitants [1]. Stroke shares many risk factors with cardiovascular diseases, such as age, hypertension smoking and dyslipidaemias. The role of adipose tissue in ischaemic stroke remains largely unknown [4]. The pathophysiological significance of plasma omentin-1 in atherosclerosis-based ischaemic stroke has not received much attention until recently [5]
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