Abstract
Aim. To estimate the role of omega-3 polyunsaturated fatty acids (PUFAs) administration in atrial fibrillation (AF) prevention after planned coronary artery bypass graft (CABG) surgery.Material and Methods. Studied were 306 patients divided into two groups: patients of group I didn’t receive PUFAs (158 patients, 82.7% males) and patients of group II received PUFAs (148 patients, 89.3% males). PUFAs were prescribed in daily dose 2000 mg 5 days before surgery and in daily dose 1000 mg in postoperative period during 21 days.Results. Postoperative AF (POAF) occurred in 29.7% patients in group I and in 16.9% patients in group II (р=0.009). We found that after CABG in patients of the I group median IL-6 level was 39.3% higher (p=0.001), interleukin-10 – 20.2% higher (p=0.01), superoxide dismutase – 78.9% higher (р<0.001), malondialdehyde – 33.8% higher (p=0.03), docosahexaenoic acid – 31.8% lower (p=0.01) and omega-3 index – 43.4% lower (p=0.04) than in patients of the II group.According to multivariate regression analysis we found significant association between the factors of inflammation, oxidative stress and the risk POAF development.Conclusions. In patients who took PUFAs, we found less activation of inflammation, oxidative stress, the increasing of docosahexaenoic acid and omega-3 index accompanied by the decreasing of POAF development rates up to 12.8%.
Highlights
We found that after coronary artery bypass graft (CABG) in patients of the I group median IL-6 level was 39.3% higher (p=0.001), interleukin-10 – 20.2% higher (p=0.01), superoxide dismutase – 78.9% higher (р
According to multivariate regression analysis we found significant association between the factors of inflammation, oxidative stress and the risk Postoperative AF (POAF) development
In patients who took polyunsaturated fatty acids (PUFAs), we found less activation of inflammation, oxidative stress, the increasing of docosahexaenoic acid and omega-3 index accompanied by the decreasing of POAF development rates up to 12.8%
Summary
При формировании дизайна исследования были приняты основополагающие принципы, отражающие соответствие исследования единым стандартам представления результатов испытания (рекомендации CONSORT) (рис. 1). Анализ данных: клинико-анамнестические показатели, эхокардиографические параметры, факторы оперативного вмешательства, показатели воспаления, окислительного стресса, миокардильного повреждения и дисфункции, омега-3 индекса (n=306). Омега ПНЖК назначались в дозе 2000 мг/сут за 5 дней до КШ и в дозе 1000 мг/сут в послеоперационном периоде в течение 21 дня, препарат выдавался пациентам в рамках исследования. Исследование лабораторных показателей было возможным у 192 пациентов. Проводилось определение содержания интерлейкинов 6 (ИЛ-6), 8 (ИЛ8) и 10 (ИЛ-10), также исследовались концентрации NT-proBNP, тропонина, супероксиддисмутазы (СОД) плазмы крови, малонового диальдегида (МДА), восстановленного глутатиона (ВГ) и активности глутатионредуктазы, омега-3 индекса. 1. Статистически значимых различий между группами по клинико-анамнестическим данным выявлено не было. Нами проводился сравнительный анализ эхокардиографических показателей между группами Окислительного стресса, миокардиального повреждения и дисфункции до КШ показала отсутствие статистически значимых различий между группами.
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