Ollier Disease Anaplastic Mixed Oligoastrocytoma

Abstract

Abstract: Ollier disease, or multiple enchondromatosis, ischaracterized by multiple, asymmetrically distributed intra-osseous cartilaginous masses in the metaphyses and diaphysesof bones. It is rarely associated with neoplasm. We report a28-year-old woman with a history of Ollier disease, who deve-loped recurrent cerebral anaplastic mixed oligoastrocytoma.Key Words: Ollier disease, enchondromatosis, malignant, braintumor(Neurosurg Q 2006;16:195–197) O llier disease is a rarely encountered nonhereditarymesodermal dysplasia, characterized by multipleenchondromatosis involving metaphyses of tubular bonesespecially and asymmetrically. Ollier disease primarilyaffects the long bones and cartilage of the joints of thearms and legs, specifically the area where the shaft andhead of a long bone meet (metaphyses). The pelvis is ofteninvolved; and even more rarely, the ribs, breast bone(sternum), and/or skull may also be affected. It is seldomseen in carpal bones.Ollier disease affects both sexes. The main compli-cations are the nature of the lump or swelling, thedeformity and shortening of the affected bones. Differ-ential diagnoses of fibrous dysplasia and diaphysealaclasis need to be considered. It is recognized thatmalignancy can occur but it is extremely rare.We described a case of Ollier disease associated withcerebral anaplastic mixed oligoastrocytoma.