Olive Oil Restores Functionality of Intracellularly Retained Mutant CNG Channel

Abstract

Membrane lipids regulate structure and function of transmembrane proteins through different mechanisms, which depend on the context of the cell type and the inherent characteristics of the protein. For instance, mechanisms that underlie lipid regulation of ion channels depend upon specific lipid-protein interactions required to maintain the proper orientation of channel domains relative to each other. Perturbations of the lipid bilayer structure and packing may have a significant impact on the channel structure and function.