Abstract
Oligonucleotides covalently linked to an 9-amino-6-chloro-3-methoxyacridine via from a trimethylene to pentamethylene linker were prepared using novel l-threoninol backbone phosphoramidites. Although all of the modified oligonucleotides could bind to the complementary oligonucleotides, the behavior of intercalation of the acridine ring was strongly affected by linker length and the base-sequence.
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