Abstract
A necessary step in the development of a candidate drug involves characterization of the drug's interactions with the natural and synthetic surfaces it encounters. In this preliminary study, the time-, solvent-, surface-, and cation-dependency of oligodeoxynucleotide (ON) adsorption was examined by measuring loss of a radiolabeled phosphodiester ON from either cell growth media or distilled, deionized water (with or without different added cations) as a function of time and surface. As expected, ON adsorption was dependent on all the factors examined. Either silica coating of surfaces or the addition of cations, EDTA or heat-inactivated serum, may be useful techniques for reducing ON adsorptive losses.
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