Abstract
BackgroundThe presence of lipid-specific oligoclonal IgM bands (LS-OCMB) in cerebrospinal fluid is associated with a more severe clinical multiple sclerosis (MS) course. ObjectiveTo investigate LS-OCMB as a prognostic biomarker of cognitive long-term outcomes in MS. MethodsNinety-nine patients underwent neuropsychological assessment. Cognitive performance between LS-OCMB– and LS-OCMB+ patients was compared adjusting by age, education, anxiety-depression, disease duration, and disability. ResultsLS-OCMB+ patients of ∼13 years of disease duration performed worse on Symbol Digit Modalities Test (SDMT) (p = 0.005). ConclusionLS-OCMB+ perform worse on information processing speed and working memory (SDMT), suggesting that LS-OCMB could be a useful biomarker for long-term cognitive outcomes.
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