Abstract
The purpose of the current study was to assess the prevalence of cyst formation at the brain-tumor interface in olfactory neuroblastoma. We used the UCLA patient-based Pathology and Radiology Head and Neck Database (UPP&R HAND) to identify the largest patient cohort reported to date with imaging and pathology data. Eighteen of thirty-one patients (58.1%) had evidence of intracranial extension on MRI, while four (22.0%) demonstrated cyst formation at the brain–tumor interface. The extent of intracranial extension was by far the strongest predictor for intracranial cyst formation, regardless of Hyams tumor grade, using a binary logistics regression model (p = 0.002) and ROC curve analysis (AUC 94.6%). Cyst formation at the brain-tumor interface was an uncommon imaging finding, and tends to occur with a larger component of intracranial tumor extension.
Highlights
Olfactory neuroblastoma, known as esthesioneuroblastoma, is an uncommon malignant neuroectodermal neoplasm that typically arises within the superior nasal cavity in proximity to the cribriform plate [1]
Patients with olfactory neuroblastoma were identified from the University of California (UCLA) UPP&R HAND Database, which comprises data on patient epidemiology, pathology, imaging and outcome of all consecutive patients seen at the UCLA Johnson Comprehensive Cancer Center between 2000 and 2013 with head and neck cancers
A Receiver Operating Characteristic (ROC) curve demonstrated an area under the curve (AUC) of 94.6% with a standard error of 0.06, p value of 0.008, and 95% confidence intervals of 83.7–100% (Figure 3b)
Summary
Known as esthesioneuroblastoma, is an uncommon malignant neuroectodermal neoplasm that typically arises within the superior nasal cavity in proximity to the cribriform plate [1]. Classic teaching regarding the imaging characteristics of these lesions includes the formation of cysts at the margin of the brain-tumor interface [2,3], the true prevalence of this finding is controversial. Using the cross-sectional UCLA patient-based Pathology and Radiology Head and Neck Database (UPP&R HAND) to identify a patient cohort with both imaging and corresponding pathology data, we evaluated the prevalence of intracranial extension in olfactory neuroblastoma and the corresponding prevalence of cysts at the brain-tumor interface. We hypothesized that cyst formation is associated with larger intracranial tumor size and higher histological tumor grade
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