Abstract
Introduction The relationship between olfactory and emotional processing is an area of increasing interest in schizophrenia research. Objectives The brain regions like orbitofrontal cortex and amygdala are involved in the processing of olfactory information. Aims Evaluation of odor identification performance and valence interaction in patients with schizophrenia. Assessment of influence blood concentration of β-endorphin and calcitonin gene-related peptide(CGRP) on odors identification. Methods 50 patients with schizophrenia and 50 healthy controls were included in the study. Schizophrenia symptoms were evaluated using PANSS. University of Pennsylvania Smell Identification Test (UPSIT) was performed in both study groups. Moreover blood concentrations of β-endorphin and CGRP were measured in all participants. Results The concentration of CGRP was significantly higher in patients sample (p Conclusions Schizophrenic patients present a unique pattern of smell identification characterized by aberrant hedonic ratings for pleasant but not unpleasant odors. Individuals with predominant negative symptoms and higher β-endorphin concentration would also be those with the greatest ability to identify negative odors.
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