Olfactory function in Parkinsonian syndromes

Abstract

Event Abstract Back to Event Olfactory function in Parkinsonian syndromes Antje Haehner1* 1 University of Dresden Medical School, Department of Otorhinolaryngology, Department of Neurology, Germany Considering the current data on smell loss in over 95% of patients with Parkinson´s disease (PD), olfactory dysfunction has to be seen as a significant marker of the disease which is even more frequent than the classical symptom tremor. Consequently, structured and validated tests of olfactory function should be routinely used in the early and differential diagnosis of PD. In clinical routine, olfactory testing is often helpful to the physician in distinguishing PD from other forms of neurodegenerative parkinsonism, such as multiple system atrophy, and progressive supranuclear palsy. Furthermore, recent data indicate that smell loss in PD appears to take place during very early stages of the disease. As shown by the Braak neuropathological staging of PD, the olfactory system is among the first neuronal populations to display Lewy body pathology. The clinical data presented in this talk indicate that unexplained olfactory loss may be associated with an increased risk of developing PD. In this session, we also present data on metabolic parkinsonism e.g., Wilson´s disease, and drug-induced parkinsonism. Wilson´s disease patients with neurological symptoms show a significant olfactory dysfunction compared to hepatic-type patients. In neuroleptic induced parkinsonism olfactory function decreases with increasing severity of extrapyramidal symptoms. Olfactory function is also damaged to varying degree in other neurodegenerative diseases, such as Alzheimer´s disease and Huntington´s disease. Conference: Summer School on Human Olfaction, Dresden, Germany, 19 Jul - 25 Jul, 2009. Presentation Type: Poster Presentation Topic: Abstracts Citation: Haehner A (2009). Olfactory function in Parkinsonian syndromes. Conference Abstract: Summer School on Human Olfaction. doi: 10.3389/conf.neuro.09.2009.12.008 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 Jul 2009; Published Online: 22 Jul 2009. * Correspondence: Antje Haehner, University of Dresden Medical School, Department of Otorhinolaryngology, Department of Neurology, Dresden, Germany, nemoABS01@frontiersin.org Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Antje Haehner Google Antje Haehner Google Scholar Antje Haehner PubMed Antje Haehner Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.