Abstract
Olfactory bulb SARS-CoV-2 infection is not paralleled by the presence of virus in other central nervous system areas.
Highlights
A number of post-mortem neuropathological studies have reported vascular, thrombotic, and ischaemic alterations in COVID-19 cases [10,11,12,13,14,15,16]
The presence of SARS-CoV-2 within central nervous system (CNS) specimens was reported to range between 0% and 53% of analysed cases across studies, including the olfactory bulbs and/or cerebral parenchyma [12,13,14,15,16]
Our group aimed to describe the neuropathological findings in SARS-CoV-2 infected patients who died during the COVID-19 pandemic, and, by using RT-PCR and immunohistochemistry (IHC), to define and quantify the presence of virus in selected areas showing pathological signs, as well as in areas of interest that might define a route of spread for the virus in the CNS
Summary
A number of post-mortem neuropathological studies have reported vascular, thrombotic, and ischaemic alterations in COVID-19 cases [10,11,12,13,14,15,16]. The presence of SARS-CoV-2 within CNS specimens was reported to range between 0% and 53% of analysed cases across studies, including the olfactory bulbs and/or cerebral parenchyma [12,13,14,15,16].
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