Abstract
To compare the olfactory bulb volumes (OBVs) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) to healthy individuals, and to assess the changes of the OBVs in patients with CRSwNP before and after the endoscopic sinus surgery (ESS) utilising magnetic resonance imaging (MRI) with specialised software. This is a prospective cohort study. Tanta University hospital (tertiary referral hospital), Egypt. Thirty patients with CRSwNP (Group A) were compared with thirty healthy individuals (Group B) as regards the OBVs. Patients with CRSwNP underwent ESS where the Smell Identification Test-40 (SIT-40) and the OBVs were assessed pre-operatively and at least 6months postoperatively. Assessment of the OBVs was carried out using MRI with specialised software. Assessment of the volumetric changes of the olfactory bulbs in patients with CRSwNP before and after endoscopic sinus surgery utilise magnetic resonance imaging. The OBVs were significantly smaller in Group A (58.94±7.96mm3 and 60.79±8.14mm3 on the right and left sides, respectively) as compared with the Group B (73.46±8.54mm3 and 72.96±9.74mm3 on the right and left sides, respectively). There was also a significant increase in the olfactory bulb volumes as well as improvement of the SIT-40 6months postoperatively in the Group A. The olfactory bulb is characterised by neural plasticity, and its volume may be affected by the peripheral olfactory function.
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