Abstract
Odor coding in Drosophila is examined at both the cellular and molecular levels. Functional analysis of individual olfactory receptor neurons (ORNs) by single-unit electrophysiology has shown that ORNs divide into discrete classes, with each class exhibiting a characteristic odor response spectrum. Extensive analysis of ORNs in the maxillary palp has revealed six such classes, which are combined in sensilla according to a strict pairing rule. In order to identify the odor receptor genes that determine the odor specificity of these ORN classes, a new algorithm was designed to search DNA databases for proteins with a particular structure, as opposed to a particular sequence. The algorithm identified a large family of genes likely to encode odor receptors. The acj6 gene, originally identified in a screen for mutants defective in olfactory behavior, encodes a transcription factor that regulates a subset of these receptor genes, and is likely to play a critical role in the process by which ORNs select which receptors to express.
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