Abstract
A new triterpenoid saponin, named oleiferasaponin A2, was isolated and identified from Camellia oleifera defatted seeds. Oleiferasaponin A2 exhibited anti-hyperlipidemic activity on HepG2 cell lines. Further study of the hypolipidemic mechanism showed that oleiferasaponin A2 inhibited fatty acid synthesis by significantly down-regulating the expression of SREBP-1c, FAS and FAS protein, while dramatically promoting fatty acid β-oxidation by up-regulating the expression of ACOX-1, CPT-1 and ACOX-1 protein. Our results demonstrate that the oleiferasaponin A2 possesses potential medicinal value for hyperlipidemia treatment.
Highlights
Hyperlipidemia is a common disease resulting from abnormal lipid metabolism, considered as one of the high-risk factors of inducing cardio-cerebrovascular disease
Twelve novel triterpenoid saponins have been extracted from Camellia oleifera Abel. seeds [10,11,12,13,14,15,16,17,18]
Our present study reveals that oleiferasaponin A2, a novel compound from Camellia oleifera defatted seeds, can accomplish lipid-lowering of HepG2 cells
Summary
Hyperlipidemia is a common disease resulting from abnormal lipid metabolism, considered as one of the high-risk factors of inducing cardio-cerebrovascular disease. Plant extracts have been studied as therapeutic agents for hyperlipidemia [4,5,6]. Saponin is a vital class of natural products, widely used in daily life and production [7,8,9]. Twelve novel triterpenoid saponins have been extracted from Camellia oleifera Abel. Seeds [10,11,12,13,14,15,16,17,18]. Is widely cultivated throughout southern China as a commercial crop with abundant edible oil in its seeds Camellia oleifera Abel. is widely cultivated throughout southern China as a commercial crop with abundant edible oil in its seeds
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