Abstract

The methanolic extract from the pericarps of Sapindus rarak DC. was found to show pancreatic lipase inhibitory activity (IC50=ca. 614μg/mL). From the extract, oleanane-type triterpene oligoglycosides, rarasaponins I–III (1–3), and raraoside A (4), were isolated together with 13 known saponins and four known sesquiterpene glycosides. Among them, several saponin constituents including rarasaponins I (1, IC50=131μM) and II (2, 172μM), and raraoside A (4, 151μM) inhibited pancreatic lipase activity, which were stronger than that of theasaponin E1 (270μM).

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