Abstract
Chromatographic separation of methanol extract of stem bark of Albizia gummifera led to the isolation of two oleanane-type triterpenoids (1 and 2), a stigmasterol derivative (3), and stigmasterol (4). The structures of the compounds were elucidated based on 1D and 2D NMR spectroscopic data and comparing with reported literature values. The crude extract and the isolated compounds were evaluated for their antibacterial activities against five bacterial strains. Compounds 1, 2, and 4 showed marginal antibacterial activity with the growth inhibition zone ranging from 6.8 to 13.2 mm against the tested bacterial strains, with compounds 2 and 4 showing significant inhibition (13.0 and 13.2 mm) against S. flexneri and S. typhimurium, respectively. While, the standard drug, gentamycin showed inhibition zone 20.0 and 24.0 mm against S. flexneri and S. typhimurium, respectively.
Highlights
Introduction e genusAlbizia comprising of more than 160 species is widely distributed in subtropical and tropical regions with the major diversity in Africa and South America [1, 2]
Smith is a species of native to sub-Saharan Africa and Madagascar [3] and commonly known in the indigenous medical system to treat various human ailments [1, 4, 5]. e extracts of different solvents have reported to possess antimicrobial [6], antigonorrheal [7], antiplasmodial, and antileishmanial [8] activities. e plant elaborates triterpenoids [5, 9] as a common metabolite with proapoptotic and antiplasmodial activities. e stem bark of A. gummifera has been commonly visited by traditional healers for the treatment of bacterial infection in the eastern part of Ethiopia
Us, hereby, we report the isolation of four compounds (1–4) (Figure 1) from the stem bark of A. gummifera along with their antibacterial activities
Summary
Introduction e genusAlbizia (family, Fabaceae) comprising of more than 160 species is widely distributed in subtropical and tropical regions with the major diversity in Africa and South America [1, 2]. Us, hereby, we report the isolation of four compounds (1–4) (Figure 1) from the stem bark of A. gummifera along with their antibacterial activities. Subfraction 4 was subjected to small column chromatography over silica gel and eluted with n-hexane in increasing gradient of ethyl acetate to afford a light yellow powder compound (1) (20 mg).
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