Abstract
An exciting fact in biology is the discovery of new and unsuspected roles for proteins whose function had been traditionally known for many years. This has been, in the past, the case for s-catenin, which was known originally as a cytoskeletal protein, before its role as a transcriptional regulator was found. It happened also with dyskerin, a pseudouridine synthase that modifi es rRNA, which recently has been identifi ed also as a component of an active telomerase complex. A recent fi nding identifi es hTERT (a reverse transcriptase subunit of telomerase) as a modulator of Wnt signalling by association with target gene chromatin [1] and histone H2AX as an activator of hypoxia-dependent angiogenesis [2].
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