OLANZAPİN VE L-KARNİTİNİN RAT TESTİS DOKUSU ÜZERİNDEKİ ETKİSİNİN ARAŞTIRILMASI

Abstract

Objective
 Olanzapine has adverse effects on sexual dysfunction.
 There are a limited number of studies showing that it
 also causes structural changes in the reproductive
 system. This study aimed to examine the effects of
 L-Carnitine on testicular damage caused by Olanzapine
 in terms of histopathological, sperm parameters, and
 biochemical aspects.
 Material and Method
 A total of 48 adult Sprague-Dawley male rats were
 used in our study. Rats were divided into 6 groups,
 8 rats in each group: the Control group (C), 200 mg/
 kg L-Carnitine administered group (LC), 2 mg/kg low
 dose Olanzapine administered group (LOZN), 2 mg/kg
 Olanzapine, and 200 mg/kg L-Carnitine administered
 group (LOZN+LC), 4 mg/kg Olanzapine administered
 group (HOZN), 4 mg/kg Olanzapine and 200 mg/
 kg L-Carnitine administered group (HOZN+LC).
 Testicular tissues were used for the determination of
 MDA, IL-1B, IL-6, TAS, TOS levels, and histological
 evaluation.
 Results
 In the groups receiving Olanzapine, a decrease in
 sperm count, an increase in MDA, IL-1β, TOS values,
 and dose-dependent histopathological changes in
 testicular tissue were observed. Histopathological
 changes were found at a lower rate in the Olanzapine
 and L-Carnitine administered groups compared to the
 Olanzapine-only groups.
 Conclusion
 It was concluded that the degenerative histological
 findings in the testicular structure observed in the
 high-dose Olanzapine administered groups might be
 caused by the oxidative stress induced by Olanzapine
 in the testicular tissue. L-Carnitine, on the other hand,
 was thought to be effective in reducing testicular
 degeneration by reducing oxidative damage.