Abstract
AbstractIn rats pressing a lever for food on a Geller‐Seifter conflict schedule with incremental electrical stimulus, the putative novel antipsychotic olanzapine (0.78 and 1.56 mg/kg po) increased conflict responding by 35% (half the maximal increase produced by chlordiazepoxide). In rats trained to discriminate between chlordiazepoxide and saline, olanzapine (0.19–1.56 mg/kg po) reduced response rate dose‐dependently; all rats chose the saline‐appropriate lever at all doses. The results replicate the moderate anticonflict effect of olanzapine and show that the subjective cue differs from that of a benzodiazepine. A possible anxiolytic action of this class of antipsychotics is proposed. © 1995 Wiley‐Liss, Inc.
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