Olanzapine Induced Rhabdomyolysis in A Schizophrenic Adult: Case Report

Abstract

Rhabdomyolysis is a syndrome characterized by acute necrosis of skeletal muscle and subsequent release of its cellular contents into the circulation. It can occur due to trauma, exercise, infections and some metabolic diseases, as well as secondary to the use of various drugs. A 34-year-old male patient with a diagnosis of schizophrenia for 2 months was brought to our emergency department by his relatives because of the intake of 350 mg of olanzapine for suicide. The patient whose extrapyramidal system findings were present and whose creatine kinase (CK) was found to be 42670 U / L in laboratory tests was hospitalized to our service because of the secondary rhabdomyolysis for the use of olanzapine. During the hospitalization period, only the medical treatment returned normalcy to the CK level, and the kidney and liver dysfunction did not develop, and the patient was discharged by psychiatric outpatient clinic control. Rhabdomyolysis is a rare and potentially serious adverse drug reaction to antipsychotic drugs. The patients should be evaluated for side effects and in terms of rhabdomyolysis facilitating factors. Especially in high doses, patients should be monitored for rhabdomyolysis, which is a serious complication, such as acute renal damage.