Abstract
Although it is reported that olanzapine (OLZ), which is an atypical antipsychotic drug, causes sexual dysfunction in men, it is noteworthy that there is not any study evaluating the toxic effects of OLZ on the male reproductive system. In the scope of this research, it was aimed to assess the reproductive toxic effects of OLZ by oral administration of 2.5, 5, or 10 mg/kg of it to male rats for 28 days. For this purpose, sperm concentration, motility and morphology, and DNA damage were determined, and histopathological examination of testis tissue was carried out in rats. Also, the levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone, which play roles in the regulation of reproductive functions, and the levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA) which play roles in reproductive pathologies as oxidative stress biomarkers, were determined. According to the results, normal sperm morphology was decreased in 5 ve 10 mg/kg OLZ-administered groups, and pathological findings were evident in the testicular structure of the OLZ-administered group when compared with the control group. It was determined that serum LH, FSH, and testosterone levels were decreased in the OLZ-administered group. Also, decreases of GSH levels in testis tissue were determined and evaluated as the markers of the oxidative stress induced by OLZ in the testis. In conclusion, it was determined that reproductive toxic effects were induced in rats by OLZ administration. This pathology was accompanied by alterations of the hormone levels and testicular oxidative stress.
Highlights
It is reported that olanzapine (OLZ), which is an atypical antipsychotic drug, causes sexual dysfunction in men, it is noteworthy that there is not any study evaluating the toxic effects of OLZ on the male reproductive system
OLZ was shown to be related to adverse effects such as amenorrhea, menstruation disorders, impotence, galactorrhea, and sexual dysfunctions accompanied by increased prolactin levels in female patients[15]
Schizophrenia is seen worldwide, having symptoms like hallucinations, introversion, and delirium; there is still insufficient knowledge of its etiology. The initiation of this disease 80% occurs at the beginning of the reproductive period, and it affects neuroendocrine parts of the brain and causes alterations of reproductive functions
Summary
It is reported that olanzapine (OLZ), which is an atypical antipsychotic drug, causes sexual dysfunction in men, it is noteworthy that there is not any study evaluating the toxic effects of OLZ on the male reproductive system. In the scope of this research, it was aimed to assess the reproductive toxic effects of OLZ by oral administration of 2.5, 5, or 10 mg/kg of it to male rats for 28 days For this purpose, sperm concentration, motility and morphology, and DNA damage were determined, and histopathological examination of testis tissue was carried out in rats. It was determined that reproductive toxic effects were induced in rats by OLZ administration This pathology was accompanied by alterations of the hormone levels and testicular oxidative stress. Konarzewska et al.[18] showed that patients treated with risperidone and olanzapine had higher prolactin levels Both agents were found to be related to reproductive hormone disorders and sexual dysfunction. This study’s main goal was to investigate the possible toxic effects of OLZ on the male reproductive system by determining sperm concentration, motility, morphology, and DNA damage and by performing the Scientific Reports | (2021) 11:4739
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
